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Semaglutide არის ახალი თაობის GLP-1 (გლუკაგონის მსგავსი პეპტიდი -1) ანალოგი. Semaglutide არის ხანგრძლივი მოქმედების დოზის ფორმა, რომელიც დაფუძნებულია ლირაგლუტიდის ძირითად სტრუქტურაზე და უფრო ეფექტურია ტიპი 2 დიაბეტის მკურნალობაში. ლირაგლუტიდთან შედარებით, სემაგლუტიდს აქვს უფრო გრძელი ცხიმის ჯაჭვი და გაზრდილი ჰიდროფობიურობა, მაგრამ სემაგლუტიდი შეცვლილია მოკლე ჯაჭვის PEG- ით და მისი ჰიდროფილურობა მნიშვნელოვნად გაუმჯობესებულია. PEG მოდიფიკაციას შეუძლია არა მხოლოდ მჭიდროდ დააკავშიროს ალბუმინი და ნიღაბი DPP-4 ფერმენტული მოქმედების ჰიდროლიზის ადგილი, არამედ შეამციროს თირკმლის ექსკრეცია, გაახანგრძლივოს ბიოლოგიური ნახევარგამოყოფის სიცოცხლე და მიაღწიოს ხანგრძლივი მიმოქცევის ეფექტს.
Semaglutide (USAN; სავაჭრო სახელი Ozempic) არის პრეპარატი, რომელიც შემუშავებულია დანიის კომპანია Novo Nordisk- ის მიერ ტიპი 2 დიაბეტის სამკურნალოდ. იგი ბაზარზეა სახელით Ozempic. როგორც გლუკაგონის მსგავსი პეპტიდი -1 რეცეპტორის აგონისტი, ის ამცირებს სისხლში შაქრის დონეს წარმოების გაზრდით. ნოვო ნორდისკის მკვლევართა ჯგუფმა ის 2012 წელს აღმოაჩინა, როგორც ლირაგლუტიდის ხანგრძლივი მოქმედების ალტერნატივა. კლინიკური კვლევები დაიწყო 2015 წელს და მე-3 ფაზა დასრულდა 2016 წელს. 2016 წლის დეკემბერში მან მიმართა FDA– ს დამტკიცებას, ხოლო 2017 წლის ოქტომბერში FDA– ს მრჩეველთა კომიტეტმა ხმა მისცა 16-0. ის შეიძლება გამოყენებულ იქნას როგორც საინექციო და ზეპირი პრეპარატი.
ლიდსის უნივერსიტეტის მკვლევარებმა 2017 წელს განაცხადეს, რომ ის ასევე შეიძლება გამოყენებულ იქნას სიმსუქნის სამკურნალოდ. ის ამცირებს შიმშილს, საკვების სურვილებს და სხეულის ცხიმს.

მოგემსახურებით თანმიმდევრული თარგმანით.  თურქული ენის თარჯიმანი 

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