Linaclotide CAS 851199-59-2

CAS NO: 851199-59-2
Molecular Formula: C59H79N15O21S6
Molecular Weight: 1526.74000
EINECS NO: 812-291-9

Appearance: White solid

Assay :≥99.00%

Density: 1.60

Boiling Point: 2045.0±65.0℃(Predicted)

Flash Point: 1190.5±34.3℃

Vapour Pressure: 0.0±0.3 mmHg at 25℃

Index of Refraction: 1.712

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) in adults.

CAS No [129311-55-3]

Synonyms

N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene ]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide

Chemical Formula C80H113ClN18O13•(C2H4O2)2

Molecular Weight 1,690.42 g/mol

Ganirelix acetate is a synthetic, non-steroidal, anti-hormonal agent of the gonadotropin releasing hormone (GnRH) receptor antagonist class. It is used in research as a building block for fine chemical and pharmaceutical synthesis. Ganirelix acetate has been shown to be useful in the synthesis of drugs that target the GnRH receptor or other receptors with high affinity for GnRH. This compound can act as an intermediate in many chemical reactions and is also a versatile scaffold for drug design.

CAS No.145672-81-7

Chemical Name:CETRORELIX

SynonymsCetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate);Cetrorelix acetate (SB-75);Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%

CBNumber:CB51478311

Molecular Formula:C70H92ClN17O14.C2H4O2

Molecular Weight:1491.11

Uses

Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.

Uses

Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.

Aviptadil CAS 40077-57-4

Product Code: BM-2-4-083
CAS number: 40077-57-4
Molecular formula: C147H238N44O42S
Molecular weight: 3325.8
EINECS number: 200-001-8
MDL No.: MFCD00167535

1. Medical field：(1) Vasodilator(2) Intestinal secretion enhancer(3) Gastrointestinal smooth muscle contraction inhibitor(4) Neuroendocrine modulators

2. Research field：(1) Vascular biology research(2) Neuroendocrine research(3) Pharmacological research

3. Industrial sector：(1) Cosmetics and perfume manufacturing(2) Food additives(3) Pharmaceutical industry.

CAS No [50-56-6]

Chemical Formula C43H66N12O12S2

Molecular Weight 1,007.19 g/mol

Natriuretic hormone; induces uterine contraction and lactation

ცხელი გაყიდვების პროდუქტები:
5Cl-ADBA წინამორბედი (ნახევრად დასრულებული)
5Cl-ADBA ნედლეული
ADBB წინამორბედი (ნახევრად დასრულებული)
ADBB ნედლეული
eutylone Crystal
2FDCK New (მცირე და დიდი კრისტალი)
იზოტონიტაზენი CAS 14188-81-8
Fluetizolam CAS: 40054-88 -4
ბრომაზოლამი CAS: 71368-80-4
პროტონიტაზენი (ჰიდროქლორიდი) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
ჩვენ სპეციალიზირებულია მაღალი ხარისხის კვლევითი ქიმიური და სამედიცინო ქიმიკატების ექსპორტზე, on. პროდუქცია ექსპორტირებულია აშშ-ში, კანადაში, საფრანგეთში, კორეაში, იაპონიაში, რუსეთში, სამხრეთ-აღმოსავლეთ აზიაში და სხვა ქვეყნებში.

CAS No.90779-69-4

Chemical Name:Atosiban

SynonymsAntocin;rwj22164;RW-22164;Atosiban;ORF22164;ORF 22164;ORF-22164;14-Deoxy-11;atosiban price;Human Atosiban

CBNumber:CB7497854

Molecular Formula:C43H67N11O12S2

Molecular Weight:994.19

Melting point >165oC (dec.)

Boiling point 1469.0±65.0 °C(Predicted)

Density 1.254±0.06 g/cm3(Predicted)

storage temp. -20°C

solubility H2O: ≤100 mg/mL

Uses

Premature labor

Uses

Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

Uses

Atosiban has been used:

• as an oxytocin receptor antagonist
• in the calcium mobilization assay for Z factor determination in uterine myometrium (UT-myo cells) and as a therapeutic agent to inhibit preterm labor
• to inhibit the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN)

Chemical Name : Ornipressin
CAS No : 3397-23-7
Molecular Formula : C45H63N13O12S2
Formula Weight : 1042.19

Density 1.320±0.06 g/cm3(Predicted)

Boling Point 1616.2±65.0 °C(Predicted)

Flash Point 931.3°C

Vapor Presure 0mmHg at 25°C

pKa 9.90±0.15(Predicted)

Storage Condition -20°C

Refractive Index 1.582

Physical and Chemical Properties Artificial synthesis of vasopressin-like substances, the 8-position arginine into ornithine, and the effect of benseri vasopressin is similar, but the vasoconstrictive effect is stronger, more rapid, intravenous injection of 3min is effective, can be maintained for more than 1H. In addition, it can increase the arterial pressure without the side effects of catecholamines. It can also prolong the action time of local anesthetics.

CAS No.37025-55-1

Chemical Name:Carbetocin

SynonymsCarbetocin Acetate;Pabal;DeaMino-2-O-Methyltyrosine-1-carbaoxytocin;d(COMOT);Duratocin;Lonactene;Depotocin;Carbansin;CARBETOCIN;Carbetoxin

CBNumber:CB9175745

Molecular Formula:C45H69N11O12S

Molecular Weight:988.17

Melting point 140 - 160°C

alpha D -69.0° (c = 0.25 in 1M acetic acid)

Boiling point 1477.9±65.0 °C(Predicted)

Density 1.218±0.06 g/cm3(Predicted)

storage temp. -15°C

Uses

Carbetocin is an obstetric drug used to control postpartum hemorrhaging.
A new synthetic analog of oxytocin, carbetocin, is long acting and also has a rapid onset of action. It is an oxytocin receptor agonist and also stimulates milk let down due to its action on oxytocin receptors of myoepithelial cells.

Terlipressin CAS 14636-12-5

CAS NO: 14636-12-5
Molecular Formula: C52H74N16O15S2
Molecular Weight: 1227.37000
EINECS NO: 238-680-8
MDL NO: NA

Appearance: White powder

Assay: ≥99.0%

Density: 1.46 g/cm3

Boiling Point: 1824ºC at 760 mmHg

Flash Point: 1056.9ºC

Refractive Index: 1.664

Vapor Pressure: 0mmHg at 25°C

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. Terlipressin is also used in the treatment of acute variceal bleeding. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding.

CAS No.130308-48-4

Chemical Name:HOE 140

SynonymsS-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP

CBNumber:CB1318492

Molecular Formula:C59H89N19O13S

Molecular Weight:1304.52

Density 1.60±0.1 g/cm3(Predicted)

storage temp. Sealed in dry,2-8°C

solubility Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM)

form powder

pka 3.60±0.21(Predicted)

color white

Description

Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].

Uses

Antagonist (bradykinin).

CAS No.4474-91-3

Chemical Name:ANGIOTENSIN II, HUMAN

SynonymsANGIOTENSIN II;Ang II;DRVYIHPF;TY-10721;AngiotensinⅡ;ANGIOTENSIN-2;H-DRVYIHPF-OH;angiotensin renin;ANTI-ANGIOTENSIN II;ile(5)-angiotensini

CBNumber:CB0338057

Molecular Formula:C50H71N13O12

Molecular Weight:1046.2

Boiling point 809.08°C (rough estimate)

Density 1.1257 (rough estimate)

refractive index 1.6700 (estimate)

RTECS BW2165000

storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility insoluble in DMSO; insoluble in EtOH; ≥100.2 mg/mL in H2O

Description

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.

Uses

Cardiopulmonary resuscitation - not yet an approved application

Uses

A peptide involved in the regulation of blood pressure

Uses

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.