CAS No.112809-51-5

Chemical Name:Letrozole

SynonymsLETROZOL;FEMARA;LETRAZOLE;LetrozoleUsp28;Letrozole(FeMara);Letroz;etrozoL;Lelrozol;Lerozole;Laiquzuo

CBNumber:CB9286355

Molecular Formula:C17H11N5

Molecular Weight:285.3

Melting point 181-183°C

Boiling point 563.5±60.0 °C(Predicted)

Density 1.21±0.1 g/cm3(Predicted)

storage temp. 2-8°C

solubility DMSO: >50mg/mL

pka 1.52±0.11(Predicted)

Uses

A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

Uses

Letrozole has been used:

in organoid growth assay to determine its inhibitory capacity(48)

to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49)

to determine its effects on tumor-induced hyperalgesia(50)

for hormonal manipulation in rats(51)

to study its effects on lipocalin-2 (Lcn2)(52)

to determine its effects on mechanical hyperalgesia and aromatase expression(53)