Detail Information
Product Name: 2-bromo-4-methylpropiophenone Cas No.:1451–82–7
Einecs No.: 696–162–0 Mf: C10H11BrO
Purity: 99.0%min Appearance: White Crystalline Powder
Melting Point: 75–77℃ Storage Temp: Refrigerator
Sample: Availiable Other Names: 4-Methylphenyl 1-BroMoethyl Ketone;2-bromo-4-methylpropiophenone

Product Description
Factory Source Yohimbine HCL CAS 65-19-0 White Aas Roids Powder USA Domestic/International
Product Name:Yohimbine HCL
Appearance :White to Yellow powder
Cas:65-19-0
molecular formula:C21H27N2O3
molecular weight :355.4501
Botanical Source:Corynante Yohimbe

Yohimbine Hydrochloride is indicated as a sympathicolytic and mydriatic. It may have activity as an aphrodisiac. Impotence (not able to have erections)The way yohimbine works is not known for sure. It is thought, however, to work by increasing the body's production of certain chemicals that help produce erections. It does not work in all men who are impotent.
New research that shows yohimbine hcl powder could be an herb with very effective antioxidant potential. Research shows it is a vasodilator, which means that it increases blood flow to the extremities and appendages.

Yohimbine hydrochloride is an α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively). Yohimbine hydrochloride is an inhibitor of alpha2A-AR, alpha2B-AR and alpha2C-AR.
References:
Anesthesia induced by administration of xylazine hydrochloride alone or in combination with ketamine hydrochloride and reversal by administration of yohimbine hydrochloride in captive Axis deer (Axis axis).  |  Sontakke, SD., et al. 2007. Am J Vet Res. 68: 20-4. PMID: 17199414
Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome.  |  Lahiri, P., et al. 2009. Blood Cells Mol Dis. 43: 105-10. PMID: 19272818
Yohimbine bioavailability in humans.  |  Guthrie, SK., et al. 1990. Eur J Clin Pharmacol. 39: 409-11. PMID: 2076728
Yohimbine hydrochloride ameliorates collagen type-II-induced arthritis targeting oxidative stress and inflammatory cytokines in Wistar rats.  |  Neha, ., et al. 2017. Environ Toxicol. 32: 619-629. PMID: 27028940
Antagonism of xylazine hydrochloride with yohimbine hydrochloride and 4-aminopyridine in captive wapiti.  |  Renecker, LA. and Olsen, CD. 1986. J Wildl Dis. 22: 91-6. PMID: 3005668
The impact of Yohimbine-induced arousal on facets of behavioural impulsivity.  |  Herman, AM., et al. 2019. Psychopharmacology (Berl). 236: 1783-1795. PMID: 30635680
Yohimbine hydrochloride inhibits benign prostatic hyperplasia by downregulating steroid 5 alpha -reductase type 2.  |  Zhao, Y., et al. 2021. Eur J Pharmacol. 908: 174334. PMID: 34265299
Immobilization of coyotes with xylazine hydrochloride-ketamine hydrochloride and antagonism by yohimbine hydrochloride.  |  Kreeger, TJ. and Seal, US. 1986. J Wildl Dis. 22: 604-6. PMID: 3503155
Yohimbine hydrochloride inhibits skin melanin synthesis by regulating wnt/ beta -catenin and p38/MAPK signal pathways.  |  Fu, T., et al. 2022. J Dermatol Sci. 107: 17-23. PMID: 35840473
Yohimbine hydrochloride reversal of ketamine hydrochloride and xylazine hydrochloride immobilization of Bengal tigers and effects on hematology and serum chemistries.  |  Seal, US., et al. 1987. J Wildl Dis. 23: 296-300. PMID: 3586208
Effect of caffeine sodium benzoate, ketamine hydrochloride, and yohimbine hydrochloride on xylazine hydrochloride-induced anorexia in white-tailed deer.  |  Van der Eems, K. and Brown, RD. 1986. J Wildl Dis. 22: 403-6. PMID: 3735587

Common Name 2,2-Diphenylacetonitrile CAS Number 86-29-3

What is Diphenylacetonitrile used for?
Diphenylacetonitrile is mainly used as an intermediate to manufacture API which deals in treatment of respiratory stimulant. Diphenylacetonitrile (CAS No. 86-29-3) is used to manufacture APIs like Aminepentamide Sulphate, Diphenoxylate, Diphenylacetaldehyde, Doxapram, Loperamide, Methadone.

Diphenylacetonitrile comprises faint yellow crystalline/white to creamy powder with an average mass of 195. 259705 da and cas no of 86-29-3

Diphenylacetonitrile is a white to creamy or faint yellow crystalline powder, Soluble in ethanol, ether. It is obtained by bromination and condensation of phenylacetonitrile. Diphenylacetonitrile is mainly used as an intermediate to manufacture API which deals in treatment of respiratory stimulant. It is used to manufacture APIs like stomach amine, Aminepentamide Sulphate, Diphenoxylate, Diphenylacetaldehyde, Doxapram, Loperamide, Methadone.Mathadone (M225865) impurity. Used in synthesis of methadone, antispasmodics and other pharmaceuticals.Diphenylacetonitrile is used to synthesize isocyanate, which is further prepared into UV paint, PU paint, transparent elastomer and adhesive, etc. In addition, it is also used in polyamide and epoxy resin industries.
To know more:

Acetaminophen is a Cox-1, Cox-2, and Cox-3 (cyclooxygenase) inhibitor. Acetaminophen may be selective for Cox-3 (IC50 values are > 1000, > 1000, and 460 μM for murine Cox-1, murine Cox-2, and canine Cox-3, respectively). Acetaminophen is a widely used analgesic and antipyretic agent.
References:
Determination of paracetamol (acetaminophen) in different body fluids and organ samples after solid-phase extraction using HPLC and an immunological method.  |  Pufal, E., et al. 2000. Fresenius J Anal Chem. 367: 596-9. PMID: 11225839
The effects of additives on the growth and morphology of paracetamol (acetaminophen) crystals.  |  Thompson, C., et al. 2004. Int J Pharm. 280: 137-50. PMID: 15265554
Metabolism of acetaminophen (paracetamol) in plants--two independent pathways result in the formation of a glutathione and a glucose conjugate.  |  Huber, C., et al. 2009. Environ Sci Pollut Res Int. 16: 206-13. PMID: 19145453
The effect of different doses of flumazenil on acetaminophen toxicity in rats.  |  Bozogluer, E., et al. 2012. Bratisl Lek Listy. 113: 525-8. PMID: 22979906
NQO2 is a reactive oxygen species generating off-target for acetaminophen.  |  Miettinen, TP. and Björklund, M. 2014. Mol Pharm. 11: 4395-404. PMID: 25313982
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey.  |  Yu, H., et al. 2015. Xenobiotica. 45: 270-7. PMID: 25335570
Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Method validation and application to a neonatal pharmacokinetic study.  |  Cook, SF., et al. 2015. J Chromatogr B Analyt Technol Biomed Life Sci. 1007: 30-42. PMID: 26571452
Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing.  |  Heard, K., et al. 2016. Br J Clin Pharmacol. 81: 562-8. PMID: 26584404
Bioinorganic Nanohybrid Catalyst for Multistep Synthesis of Acetaminophen, an Analgesic.  |  San, BH., et al. 2016. ACS Appl Mater Interfaces. 8: 30058-30065. PMID: 27797174
Deriving harmonised permitted daily exposures (PDEs) for paracetamol (acetaminophen) CAS #: 103-90-2.  |  Gromek, K., et al. 2020. Regul Toxicol Pharmacol. 115: 104692. PMID: 32522580
Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.  |  Koehn, LM., et al. 2020. F1000Res. 9: 573. PMID: 32934805